Understanding one of the world's most effective medicines – and the lessons it has taught us about medicine safety

Sodium valproate is a medicine that has been used for more than fifty years to treat a range of neurological and psychiatric conditions. For many people, it is a highly effective medicine that has transformed lives by controlling seizures and stabilising mood when other treatments have not been successful.

However, sodium valproate is also recognised as one of the most significant teratogenic medicines in modern healthcare. Exposure during pregnancy can increase the risk of congenital malformations, neurodevelopmental disorders and Fetal Valproate Spectrum Disorder (FVSD). As scientific understanding of these risks has developed, prescribing guidance and regulatory measures have changed considerably.

Today, sodium valproate remains an important medicine for many patients. At the same time, it has become central to discussions about medicine safety, informed consent, pregnancy prevention and the way medicines are monitored throughout their lifecycle.
 
Whether you are a patient, family member, healthcare professional, researcher or simply want to learn more, this Knowledge Hub brings together evidence-based information to help you understand sodium valproate, its clinical benefits, its recognised risks, and its continuing importance in medicine safety.